Publications

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD

Bodansky A, Ahyong V, Dayao M, et al. bioRxiv. 2026 (preprint). doi:10.64898/2026.05.06.722823

Clinical timeline of the index ROHHAD patient alongside the integrated AEGIS platform applied to their samples.

Molecular mimicry in multisystem inflammatory syndrome in children

Bodansky A, Mettelman RC, Sabatino JJ, et al. Nature. 2024;632(8025):622-629. PMID: 39112696

Proteome-wide PhIP-seq across 199 MIS-C patients and 45 at-risk controls defines a 30-autoantigen signature that distinguishes MIS-C.

Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR T cell therapies in autoimmunity

Bodansky A, Yu DJL, Rallistan A, et al. J Clin Invest. 2024;134(13). PMID: 38753445

Each individual carries a unique, proteome-wide autoantibody fingerprint (the "autoreactome") that stays stable over years.

Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients

Bodansky A, Wang CY, Saxena A, et al. JCI Insight. 2023;8(11). PMID: 37288661

Post-COVID anti-ARHGAP31 autoantibodies converge on a single protein region resembling a SARS-CoV-2 sequence.

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

Vazquez SE, Mann SA, Bodansky A, et al. eLife. 2022;11. PMID: 36300623

PhIP-seq screening of MIS-C and Kawasaki disease cohorts reveals only rare, largely patient-private autoantibody signals.

NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications

Bodansky A, Vazquez SE, Chou J, et al. J Allergy Clin Immunol. 2023;151(4):926-930.e2. PMID: 36509151

A patient with anti–IFN-α2 autoantibodies harbors an NFKB2 variant that disrupts p100-to-p52 processing.